Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MPL | P40238 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10171329 | 0.86 | RAB9A (0.49) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL475099 | 0.84 | RAB9A (0.50) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL474234 | 0.84 | ALDH1A1 (0.53) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL1801918 | 0.83 | ALDH1A1 (0.66) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL474243 | 0.82 | MPL (0.52) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL474416 | 0.82 | ALDH1A1 (0.48) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL474173 | 0.80 | MPL (0.47) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL474265 | 0.80 | FFAR4 (0.46) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL15580577 | 0.78 | FFAR4 (0.49) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL17412665 | 0.77 | ALDH1A1 (0.56) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708538-B1 | Process for preparing fused pyrimidine-dione derivatives, useful as as TRPA1 modulators | GLENMARK PHARMACEUTICALS SA (CH) | 2015-08-12 | — | — | EP | disclosed |