Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694647 | 0.89 | HPGD (0.60) | HPGDMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL30225654 | 0.89 | HPGD (0.60) | HPGDMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL26813893 | 0.82 | HPGD (0.55) | HPGDMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL1275770 | 0.82 | HPGD (0.55) | HPGDMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL27033132 | 0.82 | HPGD (0.55) | HPGDMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL25436703 | 0.82 | HPGD (0.55) | HPGDMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL10770035 | 0.81 | VDR (0.55) | HPGDMAPTKMT2AALDH1A1RAB9A | |
| SCHEMBL14015387 | 0.80 | SMN1; SMN2 (0.54) | HPGDMAPTKMT2AALDH1A1RAB9A | |
| SCHEMBL6716400 | 0.80 | HPGD (0.55) | HPGDMAPTKMT2AALDH1A1RAB9A | |
| SCHEMBL290900 | 0.79 | RAB9A (0.50) | HPGDMAPTKMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160332977-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20160332976-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20160332977-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20160332976-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
| WO-2015123519-A2 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2015-08-20 | — | — | WO | disclosed |
| US-20150225384-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2015-08-13 | — | — | US | disclosed |
| US-20150225384-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332976-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | HPGD 1696/4885MAPT 3607/4885KMT2A 2781/4885 |
| US-20160332977-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | HPGD 1696/4885MAPT 3607/4885KMT2A 2781/4885 |
| US-20150225384-A1 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS | KCNN2, KCNJ2, KCNN1 | HPGD 1696/4885MAPT 3607/4885KMT2A 2781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.