Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.68 |
| ▸ | NPC1 | O15118 | 11/20 | 0.68 |
| ▸ | PKM | P14618 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859672 | 0.92 | RAB9A (0.60) | RAB9ANPC1PKMKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL859401 | 0.91 | RAB9A (0.58) | RAB9ANPC1PKMKDM4EMAPT | |
| SCHEMBL14027384 | 0.79 | KDM4E (1.00) | RAB9ANPC1PKMKDM4EMAPT | |
| SCHEMBL9517906 | 0.79 | RAB9A (0.66) | RAB9ANPC1PKMKDM4EMAPT | |
| SCHEMBL16743428 | 0.74 | ALDH1A1 (0.48) | KDM4EMAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL859594 | 0.73 | KDM4E (0.86) | RAB9ANPC1PKMKDM4EMAPT | |
| SCHEMBL423547 | 0.73 | NPC1 (0.58) | RAB9ANPC1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL6483036 | 0.72 | NPC1 (0.64) | RAB9ANPC1PKMKDM4EMAPT | |
| SCHEMBL16743431 | 0.71 | KDM4E (0.54) | KDM4EMAPTSMN1; SMN2MAPK1LMNA | |
| SCHEMBL16998590 | 0.71 | ALDH1A1 (0.55) | RAB9ANPC1KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9315521-B2 | Pyrimidines as novel therapeutic agents | UNIVERSITé LAVAL (CA) | 2016-04-19 | — | — | US | disclosed |
| US-20150225423-A1 | PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS | UNIVERSITé LAVAL (CA) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225423-A1 | PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS | TYMS, P2RX2, TYMP | RAB9A 3092/4885NPC1 2501/4885PKM 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.