Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 3/20 | 0.46 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.46 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.46 |
| ▸ | TXK | P42681 | 1/20 | 0.46 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.45 |
| ▸ | STK16 | O75716 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.45 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5018907 | 0.87 | ADRB2 (0.48) | RIPK2KDRMAPK14GAKNLK | |
| SCHEMBL19499073 | 0.85 | RIPK2 (0.45) | RIPK2KDRMAPK14GAKNLK | |
| SCHEMBL5548218 | 0.80 | CCNC (0.45) | RIPK2KDRMAPK14GAKNLK | |
| SCHEMBL422643 | 0.78 | SMN1; SMN2 (0.59) | RIPK2KDRMAPK14GAKNLK | |
| SCHEMBL21138127 | 0.78 | CCNC (0.45) | RIPK2GAKAAK1CCNCCDK8 | |
| SCHEMBL16289500 | 0.78 | CCNC (0.48) | RIPK2KDRMAPK14GAKNLK | |
| SCHEMBL21173342 | 0.76 | GAK (0.48) | GAKCDK2CCNE2CCNA2CCNE1 | |
| SCHEMBL16248020 | 0.76 | CCNC (0.49) | RIPK2KDRMAPK14GAKNLK | |
| SCHEMBL19447850 | 0.76 | ADRA1A (0.51) | SLC22A12IRAK4SMN1; SMN2 | |
| SCHEMBL12120795 | 0.76 | IRAK4 (0.38) | KDRABL1LCKAURKAMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | DDR2, DDR1, DDRGK1 | RIPK2 472/4885KDR 404/4885MAPK14 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.