Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.36 |
| ▸ | TUBB | P07437 | 2/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL320775 | 0.89 | POLB (0.41) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL321051 | 0.84 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTGAATP53 | |
| SCHEMBL17004136 | 0.78 | HTT (0.39) | HTTALDH1A1LMNANPC1MAPT | |
| SCHEMBL320650 | 0.78 | HTT (0.38) | HTTALDH1A1LMNANPC1MAPT | |
| SCHEMBL321038 | 0.75 | KDM4E (0.42) | HTTALDH1A1MAPTGAATP53 | |
| SCHEMBL145768 | 0.74 | HTT (0.55) | HTTALDH1A1LMNAMAPTGAA | |
| SCHEMBL6220257 | 0.74 | HTT (0.43) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5722235 | 0.74 | HTT (0.52) | HTTALDH1A1LMNANPC1MAPT | |
| SCHEMBL321473 | 0.73 | HTT (0.41) | HTTALDH1A1LMNANPC1MAPT | |
| SCHEMBL2519397 | 0.73 | NPC1 (0.46) | HTTTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590975-B1 | INDOLIZINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2015-08-19 | — | — | EP | claimed |