Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321473 | 0.88 | HTT (0.41) | HTTALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL321028 | 0.85 | HCRTR1 (0.44) | HTTALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL321038 | 0.83 | KDM4E (0.42) | HTTALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL14916185 | 0.81 | HTT (0.39) | HTTALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL321863 | 0.80 | CA12 (0.41) | HTTALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL14916577 | 0.80 | BRD4 (0.40) | HTTALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL321471 | 0.80 | ALDH1A1 (0.39) | HTTALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL14916426 | 0.79 | MAPT (0.39) | HTTALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL12505747 | 0.79 | POLB (0.42) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL17004134 | 0.78 | HTT (0.39) | HTTALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590975-B1 | INDOLIZINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2015-08-19 | — | — | EP | claimed |