Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17004245 | 0.89 | CHRNB4 (0.43) | FAAHCHRNA7KCNH2CHRNB2CHRNB4 | |
| SCHEMBL17004220 | 0.88 | CHRNB2 (0.36) | FAAHCHRNA7CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17004293 | 0.86 | CHRNB2 (0.34) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL17004269 | 0.84 | CHRNB2 (0.35) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17004292 | 0.83 | MAOB (0.33) | CHRNA7KCNH2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17004216 | 0.83 | HCRTR1 (0.30) | FAAHHCRTR1HCRTR2RET | |
| SCHEMBL17004214 | 0.80 | HCRTR2 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL17004185 | 0.80 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL17004198 | 0.79 | FURIN (0.40) | HCRTR1HCRTR2NAAARET | |
| SCHEMBL17004324 | 0.79 | CHRNA7 (0.49) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099795-B1 | AZAADAMANTANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS | ABBVIE BAHAMAS LTD (BS) | 2015-08-19 | — | — | EP | disclosed |