Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17006351 | 1.00 | KMT2A (0.50) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL17018758 | 0.86 | RAD52 (0.45) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL16962836 | 0.84 | KMT2A (0.58) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL16962841 | 0.75 | ALDH1A1 (0.55) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL13740208 | 0.74 | KMT2A (0.64) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL16962878 | 0.73 | KCNH2 (0.71) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL16962172 | 0.72 | KCNH2 (0.71) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL19475106 | 0.72 | KMT2A (0.60) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL20915150 | 0.71 | KMT2A (0.52) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL17018760 | 0.70 | KMT2A (0.50) | KMT2AALDH1A1MAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902738-B2 | Compounds and methods for preventing, treating and/or protecting against sensory hair cell death | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2018-02-27 | — | — | US | disclosed |
| EP-2900674-B1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2017-05-31 | — | — | EP | disclosed |
| US-20160326186-A1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | FRED HUTCHINSON CANCER CENTER | 2016-11-10 | — | — | US | disclosed |
| US-9416141-B2 | Compounds and methods for preventing, treating and/or protecting against sensory hair cell death | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150232476-A1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION | 2015-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326186-A1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | BAX, CASP3, BCL2 | KMT2A 4772/4885ALDH1A1 426/4885MAPT 2252/4885 |
| US-20150232476-A1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | BAX, CASP3, BCL2 | KMT2A 4772/4885ALDH1A1 426/4885MAPT 2252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.