Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18220897 | 0.99 | TNIK (0.59) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17018729 | 0.83 | TNIK (0.59) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL17006353 | 0.82 | KCNH2 (0.59) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| Iodide SCHEMBL17006416 | 0.81 | KCNH2 (0.61) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL19807634 | 0.80 | KCNH2 (0.61) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18220888 | 0.80 | KCNH2 (0.61) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18220909 | 0.80 | TNIK (0.55) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17018728 | 0.79 | KCNH2 (0.59) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL17006386 | 0.78 | KCNH2 (0.59) | TNIKKCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18015730 | 0.78 | KCNH2 (0.71) | KCNH2MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902738-B2 | Compounds and methods for preventing, treating and/or protecting against sensory hair cell death | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2018-02-27 | — | — | US | disclosed |
| EP-2900674-B1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2017-05-31 | — | — | EP | disclosed |
| US-20160326186-A1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | FRED HUTCHINSON CANCER CENTER | 2016-11-10 | — | — | US | disclosed |
| US-9416141-B2 | Compounds and methods for preventing, treating and/or protecting against sensory hair cell death | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150232476-A1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION | 2015-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326186-A1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | BAX, CASP3, BCL2 | TNIK 1561/4885KCNH2 2265/4885CYP3A4 4871/4885 |
| US-20150232476-A1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | BAX, CASP3, BCL2 | TNIK 1561/4885KCNH2 2265/4885CYP3A4 4871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.