Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | HPGD | P15428 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500780 | 0.77 | ALDH1A1 (0.41) | LMNAMAPK1ALDH1A1HPGDMAPT | |
| SCHEMBL3392697 | 0.72 | HPGD (0.69) | HTTLMNAF2MAPK1ALDH1A1 | |
| SCHEMBL10072452 | 0.70 | LRRK2 (0.44) | HTTLMNAMAPTLRRK2SMN1; SMN2 | |
| SCHEMBL29350921 | 0.69 | ALDH1A1 (0.38) | LMNAMAPK1ALDH1A1MAPTKDM4E | |
| SCHEMBL217939 | 0.69 | ALDH1A1 (0.38) | LMNAMAPK1ALDH1A1MAPTKDM4E | |
| SCHEMBL21394022 | 0.68 | LRRK2 (0.40) | HTTLMNAMAPTLRRK2SMN1; SMN2 | |
| SCHEMBL2049511 | 0.68 | LRRK2 (0.40) | HTTLMNAALDH1A1HPGDMAPT | |
| SCHEMBL12141955 | 0.68 | PIK3CG (0.39) | HTTLMNAMAPK1ALDH1A1HPGD | |
| SCHEMBL17008720 | 0.67 | HTT (0.41) | HTTLMNAF2MAPK1ALDH1A1 | |
| SCHEMBL6700440 | 0.66 | PLCG1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105216-A1 | PYRAZINES MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2016-12-21 | — | — | EP | claimed |
| WO-2015123533-A1 | PYRAZINES MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-08-20 | — | — | WO | claimed |
| EP-3105216-A1 | PYRAZINES MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123533-A1 | PYRAZINES MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-08-20 | — | — | WO | disclosed |