Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18752609 | 0.78 | KDM4E (0.41) | HCRTR1HCRTR2KDM4ENPSR1LMNA | |
| SCHEMBL16277360 | 0.77 | DHODH (0.51) | ALOX5APFEN1HCRTR1HCRTR2KDM4E | |
| SCHEMBL19248537 | 0.76 | CYP1A2 (0.56) | ALOX5APFEN1KDM4ENPSR1KIF11 | |
| SCHEMBL30540196 | 0.74 | ALOX5AP (0.39) | ALOX5APFEN1KDM4ELMNAALDH1A1 | |
| SCHEMBL26635201 | 0.74 | ALOX5AP (0.39) | ALOX5APFEN1KDM4ELMNAALDH1A1 | |
| SCHEMBL3102205 | 0.74 | KDM4E (0.42) | ALOX5APFEN1KDM4ENPSR1LMNA | |
| SCHEMBL24689583 | 0.73 | CCR1 (0.64) | KDM4ENPSR1SMN1; SMN2KIF11CYP1A2 | |
| SCHEMBL28862771 | 0.73 | FEN1 (0.46) | ALOX5APFEN1NPSR1LMNAKIF11 | |
| SCHEMBL18003550 | 0.72 | KIF11 (0.42) | ALOX5APFEN1KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL16278041 | 0.72 | NPC1 (0.47) | KDM4ENPSR1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015123355-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS, INC. (US) | 2015-08-20 | — | — | WO | disclosed |