Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823060 | 0.87 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5807954 | 0.82 | TLR9 (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7696540 | 0.80 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL8209414 | 0.78 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL7450822 | 0.78 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL5818764 | 0.77 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL8461866 | 0.77 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL3616202 | 0.77 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL8203884 | 0.76 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| Hydrochloric Acid SCHEMBL8202348 | 0.76 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| EP-3105206-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | Universita' degli Studi di Genova (IT) | 2016-12-21 | — | — | EP | disclosed |
| CN-106255689-A | Heteroaryl syk inhibitors | 勃林格殷格翰国际有限公司 | 2016-12-21 | — | — | CN | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| WO-2015121212-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | UNIVERSITÀ DEGLI STUDI DI GENOVA (IT) | 2015-08-20 | — | — | WO | disclosed |
| WO-2015121212-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | UNIVERSITÀ DEGLI STUDI DI GENOVA (IT) | 2015-08-20 | — | — | WO | disclosed |
| CN-101674829-B | Use of 4-cyclopropylmethoxy-N- (3, 5-dichloro-1-oxidopyridin-4-yl) -5- (methoxy) pyridine-2-carboxamide for the treatment of spinal cord trauma | SANOFI AVENTIS | 2012-01-18 | — | — | CN | disclosed |
| CN-101674829-A | Use of 4-cyclopropylmethoxy-N- (3, 5-dichloro-1-oxidopyridin-4-yl) -5- (methoxy) pyridine-2-carboxamide for the treatment of spinal cord trauma | SANOFI AVENTIS | 2010-03-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | PDE4A, PDE4D, PDE4B | PDE4A 1/4885PDE4B 3/4885PDE4C 5/4885 |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | PDE4A, PDE4D, PDE2A | PDE4A 1/4885PDE4B 4/4885PDE4C 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.