Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | NOS2 | P35228 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201484 | 0.93 | KDM4E (0.57) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL8208762 | 0.93 | KDM4E (0.57) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL12853598 | 0.85 | NOS2 (0.67) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL8212461 | 0.84 | KDM4E (0.60) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL12855299 | 0.84 | KDM4E (0.60) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL8208090 | 0.83 | KDM4E (0.59) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL12853603 | 0.83 | MEN1 (0.55) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL8206868 | 0.83 | KDM4E (0.58) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL12853586 | 0.82 | ALDH1A1 (0.51) | KDM4EHSD17B10KMT2AMEN1HPGD | |
| SCHEMBL8206380 | 0.82 | KDM4E (0.51) | KDM4EHSD17B10KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132178-B1 | JNK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | disclosed |