Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205783 | 0.82 | MEN1 (0.52) | POLBSLC2A1ALDH1A1MEN1HCRTR1 | |
| SCHEMBL21776043 | 0.73 | HPGD (0.60) | ALDH1A1KMT2AHPGD | |
| SCHEMBL9415944 | 0.73 | PNMT (0.53) | SLC2A1 | |
| SCHEMBL25820326 | 0.72 | CNR1 (0.46) | ALDH1A1MEN1KMT2AKDM4ECNR2 | |
| SCHEMBL30471855 | 0.70 | PNMT (0.56) | SLC2A1 | |
| SCHEMBL12000668 | 0.70 | PNMT (0.56) | SLC2A1 | |
| SCHEMBL8198502 | 0.70 | SMN1; SMN2 (0.53) | ALDH1A1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL28386072 | 0.69 | CTSA (0.54) | POLBALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8198970 | 0.68 | ROCK2 (0.48) | ALDH1A1MEN1KMT2AHPGDBRD4 | |
| SCHEMBL12853358 | 0.68 | HPGD (0.53) | POLBALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132178-B1 | JNK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | disclosed |