Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB known ✓ | P09619 | 4/20 | 0.59 |
| ▸ | KIT known ✓ | P10721 | 4/20 | 0.59 |
| ▸ | FLT3 | P36888 | 18/20 | 0.69 |
| ▸ | CSF1R | P07333 | 16/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698709 | 0.87 | FLT3 (0.74) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698859 | 0.86 | FLT3 (0.75) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698945 | 0.86 | FLT3 (0.75) | FLT3CSF1RPDGFRBKITPDGFRA | |
| Hydrochloric Acid SCHEMBL15388687 | 0.83 | FLT3 (0.73) | FLT3CSF1RPDGFRBKITPDGFRA | |
| Hydrochloric Acid SCHEMBL15388685 | 0.83 | FLT3 (0.73) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698969 | 0.83 | FLT3 (0.79) | FLT3CSF1RPDGFRBKITPDGFRA | |
| Hydrochloric Acid SCHEMBL1698749 | 0.82 | FLT3 (0.90) | FLT3CSF1RPDGFRBKITPDGFRA | |
| Hydrochloric Acid SCHEMBL1698760 | 0.82 | FLT3 (0.90) | FLT3CSF1RPDGFRBKITPDGFRA | |
| Hydrochloric Acid SCHEMBL1698482 | 0.82 | FLT3 (0.90) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL12067858 | 0.81 | FLT3 (1.00) | FLT3CSF1RPDGFRBKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011150198-A1 | AZOLYL UREA COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |