⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31463495 | 1.00 | — | — | |
| Bromide SCHEMBL362697 | 0.97 | TSHR (0.45) | — | |
| Hydrochloric Acid SCHEMBL7667954 | 0.97 | TSHR (0.45) | — | |
| SCHEMBL1314594 | 0.79 | TRPA1 (0.42) | — | |
| SCHEMBL464794 | 0.77 | TSHR (0.53) | — | |
| O-Xylene SCHEMBL27638879 | 0.76 | TSHR (0.71) | — | |
| SCHEMBL1314056 | 0.72 | — | — | |
| SCHEMBL29881812 | 0.72 | — | — | |
| Bromide SCHEMBL4662619 | 0.72 | TSHR (0.47) | — | |
| SCHEMBL959600 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 460 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025242747-A1 | MULTI -COMPONENT FORMULATIONS OF ORGANOMETALLIC REAGENTS | MERCK PATENT GMBH (DE) | 2025-11-27 | — | — | WO | claimed |
| US-20250282729-A1 | CHEMICAL COMPOUND MANUFACTURE, NEW SALT FORM, AND THERAPEUTIC USES THEREOF | EUSTRALIS PHARMACEUTICALS LIMITED (TRADING AS PRESSURA NEURO) (AU) | 2025-09-11 | — | — | US | claimed |
| US-12351557-B2 | Chemical compound manufacture, new salt form, and therapeutic uses thereof | EUSTRALIS PHARMACEUTICALS LIMITED (AU) | 2025-07-08 | — | — | US | claimed |
| CN-114181142-B | Synthesis method of 6- (4-methylpiperazine-1-yl) -4-o-tolylpropionic nicotinamide | 浙江工业大学 | 2023-10-20 | — | — | CN | claimed |
| CN-114181142-A | Synthetic method of 6- (4-methylpiperazine-1-yl) -4-o-tolylnicotinamide | 浙江工业大学 | 2022-03-15 | — | — | CN | claimed |
| US-20220073467-A1 | Chemical Compound Manufacture, New Salt Form, And Therapeutic Uses Thereof | EUSTRALIS PHARMACEUTICALS LIMITED (TRADING AS PRESSURA NEURO) (AU) | 2022-03-10 | — | — | US | claimed |
| EP-3902793-A1 | CHEMICAL COMPOUND MANUFACTURE, NEW SALT FORM, AND THERAPEUTIC USES THEREOF | Eustralis Pharmaceuticals Limited (Trading as Pressura Neuro) (AU) | 2021-11-03 | — | — | EP | claimed |
| WO-2020132716-A1 | CHEMICAL COMPOUND MANUFACTURE, NEW SALT FORM, AND THERAPEUTIC USES THEREOF | EUSTRALIS PHARMACEUTICALS LIMITED (TRADING AS PRESSURA NEURO) (AU) | 2020-07-02 | — | — | WO | claimed |
| US-8609574-B2 | In situ olefin polymerization catalyst system | PROMERUS LLC (US) | 2013-12-17 | — | — | US | claimed |
| EP-2296811-A2 | IN SITU OLEFIN POLYMERIZATION CATALYST SYSTEM | Promerus, LLC (US) | 2011-03-23 | — | — | EP | claimed |
| US-20060211896-A1 | Process for producing 4-(2-methylphenyl)benzotrifluoride | SUMITOMO CHEMICAL COMPANY, LIMITED | 2006-09-21 | — | — | US | claimed |
| EP-1700837-A1 | Process for producing 4-(2-methylphenyl)benzotrifluoride | Sumitomo Chemical Company, Limited (JP) | 2006-09-13 | — | — | EP | claimed |
| EP-1594824-A2 | PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF | Atherogenics, Inc. (US) | 2005-11-16 | — | — | EP | claimed |
| US-20040204485-A1 | Process of preparing esters and ethers of probucol and derivatives thereof | CRABTREE ACQUISITION CO, LLC | 2004-10-14 | — | — | US | claimed |
| WO-2004062622-A2 | PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF | ATHEROGENICS, INC. (US) | 2004-07-29 | — | — | WO | claimed |
| US-20010034459-A1 | Process for preparing 4'-trifluoromethyl-2-methylbiphenyl and 4'-trifluoromethyl-biphenyl-2-carboxylic acid from o-tolylmetallates | MEUDT ANDREAS (DE) | 2001-10-25 | — | — | US | claimed |
| EP-1112991-A2 | Process for the preparation of 4'-trifluoromethyl-2-methylbiphenyl and 4'-trifluoromethylbiphenyl-2-carboxylic acid from o-tolylmetallates | Clariant GmbH (DE) | 2001-07-04 | — | — | EP | claimed |
| WO-2001044147-A1 | PROCESS FOR THE PREPARATION OF 2-METHYLBIPHENYL AND OF 2-PHENYLBENZYL BROMIDE | ALBEMARLE CORPORATION (US) | 2001-06-21 | — | — | WO | claimed |
| US-4902833-A | Bisphosphine dioxides | UNION CARBIDE CHEMICALS AND PLASTICS COMPANY INC. (US) | 1990-02-20 | — | — | US | claimed |
| EP-0152450-B1 | CATALYZED GRIGNARD COUPLING PROCESS | FMC Corporation (US) | 1989-05-03 | — | — | EP | claimed |