Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.45 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16247718 | 0.83 | KDM4E (0.43) | ALDH1A1KDM4ETDP1CYP1A2CYP2C19 | |
| SCHEMBL29143215 | 0.82 | CYP1A2 (0.44) | ALDH1A1KDM4ETDP1CYP1A2CYP2C19 | |
| SCHEMBL31432573 | 0.81 | SLC1A3 (0.53) | ALDH1A1KDM4ETDP1CYP1A2CYP2C19 | |
| SCHEMBL10819592 | 0.81 | SLC1A3 (0.53) | ALDH1A1KDM4ETDP1CYP1A2CYP2C19 | |
| SCHEMBL14315593 | 0.80 | SIGMAR1 (0.42) | ALDH1A1KDM4ETDP1CYP1A2CYP2C19 | |
| SCHEMBL18473494 | 0.80 | KDM4E (0.43) | ALDH1A1KDM4ETDP1SIGMAR1SLC18A2 | |
| SCHEMBL30487942 | 0.79 | CYP1A2 (0.50) | ALDH1A1KDM4ETDP1CYP1A2CYP2C19 | |
| SCHEMBL791971 | 0.79 | CYP1A2 (0.50) | ALDH1A1KDM4ETDP1CYP1A2CYP2C19 | |
| SCHEMBL27596064 | 0.79 | KDM4E (0.48) | ALDH1A1KDM4ETDP1CYP1A2CYP2C19 | |
| SCHEMBL586305 | 0.79 | CYP1A2 (0.52) | TDP1CYP1A2CYP2C19CYP2D6SLC18A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353066-B2 | Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150232428-A1 | SUBSTITUTED PHENYL-SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK CANADA INC. (CA) | 2015-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232428-A1 | SUBSTITUTED PHENYL-SPLEEN TYROSINE KINASE (SYK) INHIBITORS | SYK, BTK, LYN | ALDH1A1 4019/4885KDM4E 524/4885TDP1 1278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.