Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381049 | 0.75 | TDP1 (0.48) | FGFR1LMNAHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL256337 | 0.75 | FGFR1 (0.53) | FGFR1MKNK1MKNK2LTA4HJAK2 | |
| SCHEMBL29593970 | 0.75 | FGFR1 (0.53) | FGFR1MKNK1MKNK2LTA4HJAK2 | |
| SCHEMBL21534089 | 0.73 | FGFR1 (0.44) | FGFR1MKNK1MKNK2LTA4HJAK2 | |
| SCHEMBL25291568 | 0.71 | FGFR1 (0.53) | FGFR1MKNK1MKNK2LTA4HJAK2 | |
| SCHEMBL18330920 | 0.71 | FGFR1 (0.53) | FGFR1MKNK1MKNK2LTA4HJAK2 | |
| SCHEMBL4059255 | 0.71 | FGFR1 (0.53) | FGFR1MKNK1MKNK2LTA4HJAK2 | |
| SCHEMBL4448529 | 0.71 | FGFR1 (0.53) | FGFR1MKNK1MKNK2LTA4HJAK2 | |
| SCHEMBL7016970 | 0.71 | MKNK1 (0.52) | FGFR1MKNK1MKNK2JAK2JAK3 | |
| SCHEMBL1106481 | 0.70 | FGFR1 (0.49) | FGFR1LTA4HJAK2JAK3ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |