SCHEMBL17017265

SCHEMBL17017265

O=S(=O)(Cl)c1cc(O)c(F)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.42
CA1 P00915 9/20 0.36
CA2 P00918 9/20 0.36
POLB P06746 1/20 0.36
APEX1 P27695 1/20 0.36
CA9 Q16790 6/20 0.35
CA3 P07451 5/20 0.34
CA6 P23280 5/20 0.34
CA5A P35218 5/20 0.34
CA14 Q9ULX7 5/20 0.34
CA5B Q9Y2D0 5/20 0.34
CA12 O43570 4/20 0.34
CA4 P22748 4/20 0.34
CA7 P43166 4/20 0.34
CA13 Q8N1Q1 3/20 0.34
CISD1 Q9NZ45 1/20 0.34
ACLY P53396 4/20 0.33
HSD17B2 P37059 2/20 0.32
HSD17B3 P37058 1/20 0.32
HSD17B1 P14061 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31462898 1.00 TRPV4 (0.42) TRPV4CA1CA2POLBAPEX1
SCHEMBL31462899 1.00 TRPV4 (0.42) TRPV4CA1CA2POLBAPEX1
SCHEMBL1036725 0.83 TRPV4 (0.47) TRPV4CA1CA2POLBAPEX1
SCHEMBL3948181 0.81 TRPV4 (0.46) TRPV4CA1CA2POLBAPEX1
SCHEMBL26978287 0.79 TRPV4 (0.44) TRPV4CA1CA2POLBAPEX1
SCHEMBL17056247 0.79 CA3 (0.33) TRPV4CA1CA2CA9CA3
SCHEMBL5635695 0.77 TSHR (0.50) TRPV4CA1CA2POLBAPEX1
SCHEMBL3912870 0.77 TRPV4 (0.46) TRPV4CA1CA2CA9CA3
SCHEMBL2266623 0.77 CA1 (0.42) TRPV4CA1CA2POLBAPEX1
SCHEMBL3948765 0.76 TRPV4 (0.42) TRPV4CA1CA2CA9CA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3162799-B1 FLUOROALKYLATING AGENT KUMIAI CHEMICAL INDUSTRY CO (JP) 2021-03-10 EP disclosed
EP-3162799-B1 FLUOROALKYLATING AGENT KUMIAI CHEMICAL INDUSTRY CO (JP) 2021-03-10 EP disclosed
US-10696640-B2 Fluoroalkylating agent KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2020-06-30 US disclosed
US-10696640-B2 Fluoroalkylating agent KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2020-06-30 US disclosed
CN-106573896-B Fluoroalkylating agents KUMIAI CHEMICAL INDUSTRY CO.,LTD. (JP) 2019-11-01 CN disclosed
US-20190233380-A1 FLUOROALKYLATING AGENT KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2019-08-01 US disclosed
US-20190233380-A1 FLUOROALKYLATING AGENT KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2019-08-01 US disclosed
US-10308613-B2 Fluoroalkylating agent KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2019-06-04 US disclosed
US-10308613-B2 Fluoroalkylating agent KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2019-06-04 US disclosed
CN-105980354-B The manufacture method and its intermediate of pest control agent 组合化学工业株式会社 2018-04-13 CN disclosed
US-20170197920-A1 FLUOROALKYLATING AGENT IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2017-07-13 US disclosed
US-20170197920-A1 FLUOROALKYLATING AGENT IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2017-07-13 US disclosed
US-20170197920-A1 FLUOROALKYLATING AGENT IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2017-07-13 US disclosed
EP-3162799-A1 FLUOROALKYLATING AGENT Ihara Chemical Industry Co., Ltd. (JP) 2017-05-03 EP disclosed
EP-3162799-A1 FLUOROALKYLATING AGENT Ihara Chemical Industry Co., Ltd. (JP) 2017-05-03 EP disclosed
CN-106573896-A Fluoroalkylating agents 庵原化学工业株式会社 2017-04-19 CN disclosed
CN-105980354-A Method for producing harmful-organism control agent, and intermediate thereof 庵原化学工业株式会社 2016-09-28 CN disclosed
WO-2015199109-A1 FLUOROALKYLATING AGENT イハラケミカル工業株式会社 2015-12-30 WO disclosed
WO-2015122396-A1 METHOD FOR PRODUCING HARMFUL-ORGANISM CONTROL AGENT, AND INTERMEDIATE THEREOF イハラケミカル工業株式会社 2015-08-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10308613-B2 Fluoroalkylating agent AFF1, AFF4, AFF2 TRPV4 1590/4885CA1 2029/4885CA2 1015/4885
US-10696640-B2 Fluoroalkylating agent AFF1, AFF4, AFF2 TRPV4 1590/4885CA1 2029/4885CA2 1015/4885
US-20190233380-A1 FLUOROALKYLATING AGENT AFF1, AFF4, AFF2 TRPV4 1590/4885CA1 2029/4885CA2 1015/4885
US-20170197920-A1 FLUOROALKYLATING AGENT AFF1, AFF4, AFF2 TRPV4 1590/4885CA1 2029/4885CA2 1015/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.