Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19301625 | 0.77 | MAPK14 (0.43) | CYP11B2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL12677153 | 0.75 | CYP11B2 (0.46) | CYP11B2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL17008875 | 0.74 | MAPK14 (0.41) | CYP11B2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3012083 | 0.74 | MAPK13 (0.41) | CYP11B2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL17020112 | 0.72 | LMNA (0.36) | — | |
| SCHEMBL23566135 | 0.71 | MAPK14 (0.40) | CYP11B2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL20374809 | 0.71 | MAPK14 (0.43) | CYP11B2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL28192126 | 0.71 | MAPK14 (0.40) | CYP11B2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL17008899 | 0.71 | CYP11B2 (0.40) | CYP11B2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL18256012 | 0.70 | CYP11B2 (0.44) | CYP11B2MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015120768-A1 | GPR142 AGONIST COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-08-20 | — | — | WO | disclosed |