SCHEMBL1702216

SCHEMBL1702216

Cc1cc(Nc2ncccn2)nc2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.59
KMT2A Q03164 8/20 0.57
MEN1 O00255 6/20 0.57
MAPT P10636 5/20 0.57
SMN1; SMN2 Q16637 4/20 0.57
RAB9A P51151 3/20 0.57
LMNA P02545 3/20 0.57
ALDH1A1 P00352 1/20 0.55
HPGD P15428 1/20 0.55
POLB P06746 1/20 0.55
PAX8 Q06710 1/20 0.54
NPC1 O15118 2/20 0.52
CYP1A2 P05177 1/20 0.51
SLC2A1 P11166 1/20 0.51
LRRK2 Q5S007 2/20 0.50
BACE1 P56817 1/20 0.49
GAA P10253 1/20 0.46
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30044390 0.86 KDM4E (0.62) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL1702484 0.86 KDM4E (0.62) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL837692 0.81 MEN1 (0.75) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL1702797 0.80 MAP4K4 (0.57) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL11712509 0.79 KDM4E (0.65) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL31098995 0.79 KDM4E (0.65) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL1702894 0.79 KMT2A (0.53) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL837706 0.77 MEN1 (0.74) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL1702185 0.77 KDM4E (0.49) KDM4EKMT2AMEN1MAPTSMN1; SMN2
SCHEMBL1702673 0.76 MEN1 (0.57) KDM4EKMT2AMEN1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2440546-B1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA ABIVAX (FR) 2022-12-28 EP claimed
US-11014918-B2 Compounds and pharmaceutical compositions containing at least one of the compounds ABIVAX (FR) 2021-05-25 US claimed
US-20200172525-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING AT LEAST ONE OF THE COMPOUNDS ABIVAX (FR) 2020-06-04 US claimed
US-20180339981-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING ABIVAX (FR) 2018-11-29 US claimed
US-9827237-B2 Compounds useful for treating diseases caused by retroviruses ABIVAX (FR) 2017-11-28 US claimed
US-20160151348-A1 COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES ABIVAX (FR) 2016-06-02 US claimed
EP-3016656-A1 BICYCLIC COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES ABIVAX (FR) 2016-05-11 EP claimed
US-9108919-B2 Compounds useful for treating cancer ABIVAX (FR) 2015-08-18 US claimed
WO-2015001518-A1 BICYCLIC COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES SPLICOS (FR) 2015-01-08 WO claimed
US-20140080831-A1 COMPOUNDS USEFUL FOR TREATING CANCER CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE (FR) 2014-03-20 US claimed
US-20120329796-A1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA SOCIETE SPLICOS (FR) 2012-12-27 US claimed
US-20120283265-A1 COMPOUNDS USEFUL FOR TREATING AIDS SOCIETE SPLICOS (FR) 2012-11-08 US claimed
US-20120277230-A1 COMPOUNDS USEFUL FOR TREATING CANCER SOCIETE SPLICOS (FR) 2012-11-01 US claimed
EP-2440547-A2 COMPOUNDS USEFUL FOR TREATING AIDS Société Splicos (FR) 2012-04-18 EP claimed
EP-2440545-A2 COMPOUNDS USEFUL FOR TREATING CANCER Société Splicos (FR) 2012-04-18 EP claimed
WO-2010143169-A2 COMPOUNDS USEFUL FOR TREATING AIDS SOCIÉTÉ SPLICOS (FR) 2010-12-16 WO claimed
WO-2010143168-A2 COMPOUNDS USEFUL FOR TREATING CANCER SOCIÉTÉ SPLICOS (FR) 2010-12-16 WO claimed
US-20240343716-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING ABIVAX (FR) 2024-10-17 US disclosed
WO-2010143169-A2 COMPOUNDS USEFUL FOR TREATING AIDS SOCIÉTÉ SPLICOS (FR) 2010-12-16 WO disclosed
WO-2010143168-A2 COMPOUNDS USEFUL FOR TREATING CANCER SOCIÉTÉ SPLICOS (FR) 2010-12-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120283265-A1 COMPOUNDS USEFUL FOR TREATING AIDS CBR1, CNR1, CBR3 KDM4E 3299/4885KMT2A 2336/4885MEN1 3647/4885
US-20120277230-A1 COMPOUNDS USEFUL FOR TREATING CANCER CBR1, CBR3, NCOR1 KDM4E 2650/4885KMT2A 1666/4885MEN1 1925/4885
US-11014918-B2 Compounds and pharmaceutical compositions containing at least one of the compounds TP53, BRCA1, LIMS1 KDM4E 2378/4885KMT2A 3542/4885MEN1 663/4885
US-20240343716-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING RCOR1, NR3C1, NR5A1 KDM4E 3655/4885KMT2A 1667/4885MEN1 2482/4885
US-20120329796-A1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA NR2C2, NCOR2, NR4A2 KDM4E 3675/4885KMT2A 2740/4885MEN1 3042/4885
US-20180339981-A1 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING RCOR1, NR3C1, NR5A1 KDM4E 3655/4885KMT2A 1667/4885MEN1 2482/4885
US-20160151348-A1 COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES RCOR1, CBR1, RCOR3 KDM4E 2880/4885KMT2A 1742/4885MEN1 2704/4885
US-20200172525-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING AT LEAST ONE OF THE COMPOUNDS TP53, BRCA1, LIMS1 KDM4E 2378/4885KMT2A 3542/4885MEN1 663/4885
US-20140080831-A1 COMPOUNDS USEFUL FOR TREATING CANCER NR1H4, NR1H3, NCOR1 KDM4E 3883/4885KMT2A 1903/4885MEN1 1720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.