Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | CCR9 | P51686 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 4/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22447720 | 0.90 | ALPL (0.48) | ALPLLMNATHRBMTORPIK3CA | |
| SCHEMBL15462779 | 0.87 | PIK3CA (0.51) | ALPLLMNASLC22A12MTORPIK3CA | |
| SCHEMBL15559069 | 0.86 | ALPL (0.52) | ALPLMTORPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL17022159 | 0.85 | SLC22A12 (0.60) | ALPLSLC22A12PIK3CAKMT2A | |
| SCHEMBL22508714 | 0.84 | ALPL (0.50) | ALPLLMNATP53CCR9CCR2 | |
| SCHEMBL789462 | 0.83 | ALPL (0.49) | ALPLLMNATP53KMT2AHTT | |
| SCHEMBL15459550 | 0.83 | ALPL (0.51) | ALPLLMNATP53MTORPIK3CA | |
| SCHEMBL15462778 | 0.83 | ALPL (0.51) | ALPLLMNAMTORPIK3CAKMT2A | |
| SCHEMBL15650005 | 0.82 | ALPL (0.50) | ALPLMTORPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL790824 | 0.82 | ALPL (0.56) | ALPLMTORPIK3CAPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015120737-A1 | SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS, PREPARATION METHODS THEREFOR AND USES THEREOF | 北大方正集团有限公司 | 2015-08-20 | — | — | WO | disclosed |