Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 9/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29758961 | 0.99 | F11 (0.50) | F11KLKB1F10PLATNPC1 | |
| Hydrochloric Acid SCHEMBL29758967 | 0.99 | F11 (0.50) | F11KLKB1F10PLATNPC1 | |
| SCHEMBL18241797 | 0.89 | SSTR1 (0.47) | F11KLKB1SCN10AS1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL17008937 | 0.88 | SSTR1 (0.47) | F11KLKB1SCN10AS1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL17008908 | 0.88 | SSTR1 (0.47) | F11KLKB1SCN10AS1PR4S1PR1 | |
| SCHEMBL1196381 | 0.80 | F11 (0.51) | F11KLKB1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16836933 | 0.80 | SSTR1 (0.62) | F11KLKB1SCN10ASSTR1 | |
| SCHEMBL1197333 | 0.79 | F11 (0.63) | F11KLKB1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1197057 | 0.79 | F11 (0.63) | F11KLKB1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1197260 | 0.79 | SMN1; SMN2 (0.44) | F11KLKB1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676723-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP (US) | 2017-06-13 | — | — | US | disclosed |
| US-20160340315-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-11-24 | — | — | US | disclosed |
| WO-2015123091-A1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340315-A1 | FACTOR XIa INHIBITORS | F11, SERPINC1, TFPI | F11 1/4885KLKB1 14/4885F10 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.