Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023029 | 0.91 | FGFR3 (0.50) | FGFR3MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL17023176 | 0.88 | FGFR3 (0.80) | FGFR3KDRLCKSRCKIT | |
| SCHEMBL12678315 | 0.86 | FGFR3 (0.75) | FGFR3MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL17023074 | 0.83 | FGFR3 (0.59) | FGFR3DRD2DRD4MAPTKDM4E | |
| SCHEMBL17023142 | 0.83 | FGFR3 (0.52) | FGFR3DRD2DRD3ADRA1AMAPT | |
| SCHEMBL17023062 | 0.78 | FGFR3 (0.66) | FGFR3MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL12678316 | 0.76 | FGFR3 (0.62) | FGFR3MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1126305 | 0.76 | FGFR3 (1.00) | FGFR3 | |
| SCHEMBL17023015 | 0.75 | L3MBTL1 (0.54) | FGFR3MAPTSMN1; SMN2RAB9AKDM4E | |
| SCHEMBL17023031 | 0.73 | FGFR3 (0.65) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |