Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 5/20 | 0.52 |
| ▸ | WNT1 | P04628 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023180 | 0.91 | NPC1 (0.49) | FGFR3MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12678269 | 0.87 | FGFR3 (0.63) | FGFR3WNT1DYRK1AMAPTNPC1 | |
| SCHEMBL17023161 | 0.83 | FGFR3 (0.61) | FGFR3DRD2ADRA1ADRD3MAPT | |
| SCHEMBL17023074 | 0.80 | FGFR3 (0.59) | FGFR3DRD2HSP90AA1MAPTKDM4E | |
| SCHEMBL17023176 | 0.79 | FGFR3 (0.80) | FGFR3 | |
| SCHEMBL1126298 | 0.78 | FGFR3 (0.60) | FGFR3MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17023034 | 0.78 | FGFR3 (0.49) | FGFR3WNT1DYRK1AHSP90AA1RAB9A | |
| SCHEMBL17023029 | 0.74 | FGFR3 (0.50) | FGFR3MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17023072 | 0.74 | GAA (0.53) | HSP90AA1MAPTNPC1RAB9AESR2 | |
| SCHEMBL17023126 | 0.74 | FGFR3 (0.77) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |