Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699614 | 0.88 | LMNA (0.36) | CSF1RLMNAMAPTALDH1A1TDP1 | |
| SCHEMBL1699441 | 0.73 | PTGDR2 (0.37) | CSF1RMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL1701370 | 0.71 | CSF1R (0.41) | CSF1RLMNAMAPTALDH1A1TDP1 | |
| SCHEMBL15165287 | 0.71 | CSF1R (0.40) | CSF1RMAPTALDH1A1TDP1HPGD | |
| SCHEMBL1699598 | 0.69 | CXCR1 (0.31) | MAPTALDH1A1TDP1KMT2AKDM4E | |
| SCHEMBL1699534 | 0.66 | CSF1R (0.47) | CSF1RALDH1A1TDP1HPGDCYP1A2 | |
| SCHEMBL1701364 | 0.65 | CSF1R (0.41) | CSF1RLMNAMAPTALDH1A1TDP1 | |
| SCHEMBL12630098 | 0.64 | RXFP1 (0.57) | LMNAALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL1699564 | 0.63 | HTT (0.42) | CSF1RALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL10271593 | 0.63 | CYP3A4 (0.38) | LMNAMAPTALDH1A1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588450-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003497-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |