⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17025855 | 0.98 | — | — | |
| SCHEMBL29155285 | 0.98 | — | — | |
| SCHEMBL18742486 | 0.93 | — | — | |
| SCHEMBL18742437 | 0.88 | SLC6A4 (0.35) | — | |
| SCHEMBL2874718 | 0.82 | CTSD (0.40) | — | |
| Hydrochloric Acid SCHEMBL2873437 | 0.80 | CTSD (0.39) | — | |
| SCHEMBL16266663 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL16266563 | 0.78 | — | — | |
| SCHEMBL7093776 | 0.77 | SLC6A3 (0.57) | — | |
| SCHEMBL8247834 | 0.77 | SLC6A3 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884850-B2 | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-9884850-B2 | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-9884850-B2 | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20170096413-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HDAC6 SELECTIVE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170096413-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HDAC6 SELECTIVE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170096413-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HDAC6 SELECTIVE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. | 2017-04-06 | — | — | US | disclosed |
| US-9464073-B2 | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-9464073-B2 | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-9464073-B2 | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150239869-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HDAC6 SELECTIVE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. | 2015-08-27 | — | — | US | disclosed |