SCHEMBL17026460

SCHEMBL17026460

COc1ccc(C(OC[C@@H]2O[C@@H](n3cnc4c(=O)n(C/C=C(\C)CC/C=C(\C)CCC=C(C)C)cnc43)C[C@@H]2N(CCC#N)P(OC(C)C)OC(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TYMP P19971 12/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17026489 0.84 TYMP (0.54) TYMP
SCHEMBL17026488 0.84 TYMP (0.54) TYMP
SCHEMBL16964907 0.84 TYMP (0.55) TYMP
SCHEMBL16964904 0.84 TYMP (0.55) TYMP
SCHEMBL17026392 0.83 TYMP (0.42) TYMP
SCHEMBL17026520 0.68 TYMP (0.30) TYMP
SCHEMBL30274727 0.68 TYMP (0.60) TYMP
SCHEMBL30274714 0.68 TYMP (0.60) TYMP
SCHEMBL17026454 0.68 TYMP (0.30) TYMP
SCHEMBL17037313 0.68 HIF1A (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2900681-B1 PHARMACEUTICAL COMPOSITION COMPRISING LIPOPHILIC NUCLEOSIDES IONOVATION GMBH (DE) 2019-07-10 EP disclosed
US-20190175633-A1 REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS IONOVATION GMBH (DE) 2019-06-13 US disclosed
US-20150240295-A1 REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS IONOVATION GMBH (DE) 2015-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150240295-A1 REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS NCL, NOP2, POLRMT TYMP 30/4885
US-20190175633-A1 REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS NCL, NOP2, HNRNPD TYMP 79/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.