Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MMP14 | P50281 | 1/20 | 0.56 |
| ▸ | ACACB | O00763 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17026740 | 0.88 | MMP2 (0.74) | MMP2MMP9MMP14ACACBMMP1 | |
| SCHEMBL17039176 | 0.87 | MMP2 (0.51) | MMP2MMP9MMP14ACACBMMP1 | |
| SCHEMBL28346942 | 0.83 | MMP2 (0.58) | MMP2MMP9MMP14ACACBMMP1 | |
| SCHEMBL17026726 | 0.80 | MMP2 (0.58) | MMP2MMP9MMP14MMP1 | |
| SCHEMBL17039179 | 0.76 | MMP2 (0.67) | MMP2MMP9MMP14ACACBMMP1 | |
| SCHEMBL18383659 | 0.74 | MMP2 (0.78) | MMP2MMP9MMP14ACACBMAPT | |
| SCHEMBL17039265 | 0.72 | MMP2 (1.00) | MMP2MMP9MMP14MMP1 | |
| SCHEMBL17039263 | 0.72 | MMP2 (1.00) | MMP2MMP9MMP14MMP1 | |
| SCHEMBL17026736 | 0.71 | ACACB (0.53) | ACACBMAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL4292169 | 0.71 | MMP2 (0.67) | MMP2MMP9MMP14MMP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107905-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | University of Notre Dame du Lac (US) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015127302-A1 | SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-08-27 | — | — | WO | disclosed |