SCHEMBL17028014

SCHEMBL17028014

Nc1nn(Cc2ccc(C(F)(F)F)cc2)c2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 3/20 0.53
FSCN1 Q16658 1/20 0.53
NR1H2 P55055 1/20 0.44
NR1H3 Q13133 1/20 0.44
APP P05067 2/20 0.44
HTR6 P50406 1/20 0.43
CNR1 P21554 2/20 0.43
CNR2 P34972 2/20 0.43
ACHE P22303 1/20 0.43
GRM2 Q14416 2/20 0.41
PDE8B O95263 1/20 0.41
ADORA2A P29274 1/20 0.41
ADORA1 P30542 1/20 0.41
CPT1A P50416 1/20 0.41
PTGS2 P35354 1/20 0.40
HDAC1 Q13547 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30495279 1.00 PTGER4 (0.53) PTGER4FSCN1NR1H2NR1H3APP
SCHEMBL30695091 0.86 MAT2A (0.42) PTGER4FSCN1NR1H2NR1H3GRM2
SCHEMBL17038805 0.86 MAT2A (0.42) PTGER4FSCN1NR1H2NR1H3GRM2
SCHEMBL17038931 0.86 PTGER4 (0.42) PTGER4FSCN1NR1H2NR1H3CNR1
SCHEMBL18937376 0.84 CNR1 (0.46) PTGER4HTR6CNR1CNR2ACHE
SCHEMBL14288005 0.84 CNR1 (0.50) PTGER4NR1H2NR1H3CNR1CNR2
SCHEMBL14380101 0.83 CNR1 (0.47) PTGER4FSCN1NR1H2NR1H3APP
SCHEMBL958473 0.83 CNR1 (0.58) PTGER4CNR1CNR2ACHEGRM2
SCHEMBL17028039 0.83 PTGER4 (0.53) PTGER4FSCN1NR1H2NR1H3HTR6
SCHEMBL30495115 0.83 PTGER4 (0.53) PTGER4FSCN1NR1H2NR1H3HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250333411-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY (US) 2025-10-30 US disclosed
US-12168658-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2024-12-17 US disclosed
US-20240124449-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN NOVITA PHARMACEUTICALS, INC. (US) 2024-04-18 US disclosed
US-11858929-B2 Compounds and methods for inhibiting fascin CORNELL UNIVERSITY (US) 2024-01-02 US disclosed
US-11858929-B2 Compounds and methods for inhibiting fascin CORNELL UNIVERSITY (US) 2024-01-02 US disclosed
US-11858929-B2 Compounds and methods for inhibiting fascin CORNELL UNIVERSITY (US) 2024-01-02 US disclosed
US-20230310378-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR NOVITA PHARMACEUTICALS, INC. (US) 2023-10-05 US disclosed
US-20230310378-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR NOVITA PHARMACEUTICALS, INC. (US) 2023-10-05 US disclosed
US-11701342-B2 Co-therapies including a metastasis inhibitor CORNELL UNIVERSITY (US) 2023-07-18 US disclosed
US-11701342-B2 Co-therapies including a metastasis inhibitor CORNELL UNIVERSITY (US) 2023-07-18 US disclosed
US-20170158692-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2017-06-08 US disclosed
US-9573946-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2017-02-21 US disclosed
US-9573946-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2017-02-21 US disclosed
US-9573946-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2017-02-21 US disclosed
EP-3107902-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") (US) 2016-12-28 EP disclosed
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2015-10-22 US disclosed
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2015-10-22 US disclosed
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2015-10-22 US disclosed
WO-2015127125-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY (US) 2015-08-27 WO disclosed
WO-2015127125-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY (US) 2015-08-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124449-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF PTGER4 4107/4885FSCN1 1/4885NR1H2 3805/4885
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF PTGER4 4107/4885FSCN1 1/4885NR1H2 3805/4885
US-20250333411-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF PTGER4 4107/4885FSCN1 1/4885NR1H2 3805/4885
US-11858929-B2 Compounds and methods for inhibiting fascin FSCN1, MTPN, MYOF PTGER4 4107/4885FSCN1 1/4885NR1H2 3805/4885
US-20230310378-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR MIF, CXCL10, CCL2 PTGER4 4560/4885FSCN1 1017/4885NR1H2 4182/4885
US-12168658-B2 Compounds and methods for inhibiting fascin FSCN1, MTPN, MYOF PTGER4 4107/4885FSCN1 1/4885NR1H2 3805/4885
US-20170158692-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF PTGER4 4107/4885FSCN1 1/4885NR1H2 3805/4885
US-11701342-B2 Co-therapies including a metastasis inhibitor MIF, CXCL10, CCL2 PTGER4 4560/4885FSCN1 1017/4885NR1H2 4182/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.