SCHEMBL17028038

SCHEMBL17028038

Nc1n[nH]c2cncc(Cl)c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.56
BTK Q06187 3/20 0.43
KDR P35968 4/20 0.40
PDPK1 O15530 4/20 0.39
JAK2 O60674 3/20 0.39
JAK1 P23458 2/20 0.39
TYK2 P29597 2/20 0.39
JAK3 P52333 2/20 0.39
PRKACA P17612 3/20 0.37
CDK2 P24941 3/20 0.37
LCK P06239 2/20 0.37
CSF1R P07333 2/20 0.37
LYN P07948 2/20 0.37
SRC P12931 2/20 0.37
BLK P51451 2/20 0.37
PLK4 O00444 1/20 0.37
AURKA O14965 1/20 0.37
CDK1 P06493 1/20 0.37
FGFR1 P11362 1/20 0.37
RPS6KB1 P23443 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5550935 0.76 BTK (0.43) GAABTKKDRPDPK1JAK2
SCHEMBL1848211 0.76 GAA (0.32) GAAGRIA1CACNG8
SCHEMBL31190661 0.76 GAA (0.32) GAAGRIA1CACNG8
SCHEMBL7703073 0.76 ADORA2A (0.34) GAABTKGRIA1CACNG8
SCHEMBL186280 0.72 GAA (1.00) GAAKDRPDPK1JAK2JAK1
SCHEMBL6927615 0.72 BTK (0.50) GAABTKKDRPDPK1PRKACA
SCHEMBL1703256 0.69 BTK (0.67) BTKKDRPDPK1JAK2TYK2
SCHEMBL16681057 0.69 GAA (0.58) GAAKDRPDPK1JAK2JAK1
SCHEMBL12325103 0.68 GAA (0.61) GAAKDRPDPK1JAK2JAK1
SCHEMBL31261144 0.66 GAA (0.49) GAAKDRPDPK1JAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124177-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR NOVITA PHARMACEUTICALS, INC. (US) 2026-05-07 US disclosed
US-12508245-B2 Co-therapies including a metastasis inhibitor NOVITA PHARMACEUTICALS, INC. (US) 2025-12-30 US disclosed
US-20250333411-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY (US) 2025-10-30 US disclosed
US-12168658-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2024-12-17 US disclosed
US-20240124449-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN NOVITA PHARMACEUTICALS, INC. (US) 2024-04-18 US disclosed
US-11858929-B2 Compounds and methods for inhibiting fascin CORNELL UNIVERSITY (US) 2024-01-02 US disclosed
US-11858929-B2 Compounds and methods for inhibiting fascin CORNELL UNIVERSITY (US) 2024-01-02 US disclosed
US-11858929-B2 Compounds and methods for inhibiting fascin CORNELL UNIVERSITY (US) 2024-01-02 US disclosed
US-20230310378-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR NOVITA PHARMACEUTICALS, INC. (US) 2023-10-05 US disclosed
US-20230310378-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR NOVITA PHARMACEUTICALS, INC. (US) 2023-10-05 US disclosed
US-20170158692-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2017-06-08 US disclosed
US-9573946-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2017-02-21 US disclosed
US-9573946-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2017-02-21 US disclosed
US-9573946-B2 Compounds and methods for inhibiting fascin NOVITA PHARMACEUTICALS, INC. (US) 2017-02-21 US disclosed
EP-3107902-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") (US) 2016-12-28 EP disclosed
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2015-10-22 US disclosed
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2015-10-22 US disclosed
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY 2015-10-22 US disclosed
WO-2015127125-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY (US) 2015-08-27 WO disclosed
WO-2015127125-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN CORNELL UNIVERSITY (US) 2015-08-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124449-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF GAA 630/4885BTK 4560/4885KDR 4832/4885
US-12508245-B2 Co-therapies including a metastasis inhibitor PDCD1, CD274, PDCD4 GAA 4225/4885BTK 349/4885KDR 1516/4885
US-20150299191-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF GAA 630/4885BTK 4560/4885KDR 4832/4885
US-20250333411-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF GAA 630/4885BTK 4560/4885KDR 4832/4885
US-11858929-B2 Compounds and methods for inhibiting fascin FSCN1, MTPN, MYOF GAA 630/4885BTK 4560/4885KDR 4832/4885
US-20230310378-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR MIF, CXCL10, CCL2 GAA 3948/4885BTK 715/4885KDR 589/4885
US-12168658-B2 Compounds and methods for inhibiting fascin FSCN1, MTPN, MYOF GAA 630/4885BTK 4560/4885KDR 4832/4885
US-20170158692-A1 COMPOUNDS AND METHODS FOR INHIBITING FASCIN FSCN1, MTPN, MYOF GAA 630/4885BTK 4560/4885KDR 4832/4885
US-20260124177-A1 CO-THERAPIES INCLUDING A METASTASIS INHIBITOR CCR10, CCR4, OGFR GAA 4826/4885BTK 1717/4885KDR 397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.