Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | PIP4K2A | P48426 | 4/20 | 0.36 |
| ▸ | PIP4K2B | P78356 | 4/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1702728 | 0.96 | CYP3A4 (0.50) | CYP3A4PIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL16143948 | 0.86 | CYP3A4 (0.59) | CYP3A4PIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL16143915 | 0.86 | CYP3A4 (0.54) | CYP3A4PIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL16508271 | 0.82 | CYP3A4 (0.46) | CYP3A4PIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL2691334 | 0.81 | CYP3A4 (0.50) | CYP3A4PIP4K2APIP4K2BPIP4K2CIKBKB | |
| SCHEMBL1725631 | 0.79 | CYP3A4 (0.46) | CYP3A4PIP4K2APIP4K2BPIP4K2CJAK2 | |
| SCHEMBL2692862 | 0.78 | CYP3A4 (0.45) | CYP3A4PIP4K2APIP4K2BPIP4K2CIKBKB | |
| SCHEMBL12302462 | 0.78 | KIF11 (0.37) | CYP3A4JAK2JAK1TYK2JAK3 | |
| SCHEMBL13047380 | 0.78 | CYP3A4 (0.38) | CYP3A4 | |
| SCHEMBL2692591 | 0.76 | CYP3A4 (0.49) | CYP3A4PIP4K2APIP4K2BPIP4K2CIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440528-B1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-10-08 | — | — | EP | claimed |
| EP-2440528-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-04-18 | — | — | EP | claimed |
| WO-2010142656-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-16 | — | — | WO | claimed |
| US-20100311760-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | DE VICENTE FIDALGO JAVIER | 2010-12-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311760-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | EIF2AK2, XDH, GTF3C4 | CYP3A4 50/4885PIP4K2A 2111/4885PIP4K2B 1750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.