Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17028440 | 1.00 | ALDH1A1 (0.33) | ALDH1A1TDP1 | |
| SCHEMBL16503512 | 0.79 | LMNA (0.33) | — | |
| SCHEMBL6496531 | 0.78 | ALDH1A1 (0.39) | ALDH1A1TDP1 | |
| SCHEMBL6484089 | 0.78 | ALDH1A1 (0.39) | ALDH1A1TDP1 | |
| SCHEMBL13906596 | 0.74 | LMNA (0.35) | ALDH1A1TDP1 | |
| SCHEMBL13906594 | 0.74 | LMNA (0.35) | ALDH1A1TDP1 | |
| SCHEMBL17911651 | 0.74 | LMNA (0.35) | ALDH1A1TDP1 | |
| SCHEMBL5702689 | 0.73 | — | — | |
| SCHEMBL14267356 | 0.73 | ALDH1A1 (0.40) | ALDH1A1TDP1 | |
| SCHEMBL6525612 | 0.72 | ATM (0.39) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718645-B2 | Macrocyclic therapeutic agents, methods of manufacture, and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-08-08 | — | — | US | disclosed |
| EP-3107919-B1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | UNIV FLORIDA (US) | 2021-01-27 | — | — | EP | disclosed |
| US-20200317732-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2020-10-08 | — | — | US | disclosed |
| US-20190241611-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-08-08 | — | — | US | disclosed |
| US-20170057996-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2017-03-02 | — | — | US | disclosed |
| EP-3107919-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | University of Florida Research Foundation (US) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015127161-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2015-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718645-B2 | Macrocyclic therapeutic agents, methods of manufacture, and methods of treatment | NFATC1, MCL1, ICOS | ALDH1A1 2615/4885TDP1 3096/4885 |
| US-20200317732-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | NFATC1, MCL1, ICOS | ALDH1A1 2615/4885TDP1 3096/4885 |
| US-20170057996-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | NFATC1, MCL1, ICOS | ALDH1A1 2615/4885TDP1 3096/4885 |
| US-20190241611-A1 | MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT | NFATC1, MCL1, ICOS | ALDH1A1 2615/4885TDP1 3096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.