Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.79 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.74 |
| ▸ | MAOA | P21397 | 8/20 | 0.70 |
| ▸ | MAOB | P27338 | 8/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.67 |
| ▸ | PTPRF | P10586 | 1/20 | 0.67 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.67 |
| ▸ | PTPRB | P23467 | 1/20 | 0.67 |
| ▸ | ACP1 | P24666 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | MMP3 | P08254 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.61 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15816575 | 0.90 | ENPP2 (0.77) | ENPP2AKR1B1MAOAMAOBPTPN1 | |
| SCHEMBL15816576 | 0.90 | ENPP2 (0.77) | ENPP2AKR1B1MAOAMAOBPTPN1 | |
| SCHEMBL15816578 | 0.90 | ENPP2 (0.77) | ENPP2AKR1B1MAOAMAOBPTPN1 | |
| SCHEMBL14564276 | 0.88 | ENPP2 (1.00) | ENPP2AKR1B1MAOAMAOBPTPN1 | |
| SCHEMBL15818349 | 0.85 | MAPK1 (0.83) | ENPP2MAOAMAOBMAPK1 | |
| SCHEMBL15818347 | 0.85 | MAPK1 (0.83) | ENPP2MAOAMAOBMAPK1 | |
| SCHEMBL15818348 | 0.85 | MAPK1 (0.83) | ENPP2MAOAMAOBMAPK1 | |
| SCHEMBL20534415 | 0.85 | AKR1B1 (1.00) | ENPP2AKR1B1PTPN1PTPRFPTPN2 | |
| SCHEMBL20534413 | 0.85 | AKR1B1 (1.00) | ENPP2AKR1B1PTPN1PTPRFPTPN2 | |
| SCHEMBL6694148 | 0.84 | ENPP2 (0.87) | ENPP2AKR1B1MAOAMAOBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115122-B2 | Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2015-08-25 | — | — | US | disclosed |