Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 6/20 | 0.36 |
| ▸ | KDM1A | O60341 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17546371 | 0.81 | DRD2 (0.42) | DRD2DRD3KCNH2OPRM1OPRD1 | |
| SCHEMBL11789163 | 0.78 | MAOB (0.48) | MAOBKDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL730010 | 0.76 | SLC6A2 (0.50) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL730057 | 0.74 | SLC6A4 (0.43) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL728269 | 0.73 | SLC6A4 (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17552322 | 0.72 | MAOB (0.45) | MAOBKDM1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10193127 | 0.71 | SIGMAR1 (0.43) | DRD2DRD3OPRM1OPRD1OPRK1 | |
| SCHEMBL14216707 | 0.67 | KDM1A (0.30) | KDM1A | |
| SCHEMBL11763463 | 0.66 | MAPK1 (0.44) | OPRM1MAOBKDM1ASLC6A4MAOA | |
| SCHEMBL14336785 | 0.64 | KDM4A (0.43) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649069-B1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2015-08-26 | — | — | EP | disclosed |