Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10494811 | 0.83 | ALDH1A1 (0.44) | HTTALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL9612063 | 0.81 | ALDH1A1 (0.41) | HTTALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL18571231 | 0.80 | KMT2A (0.45) | HTTALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL16000110 | 0.80 | ALDH1A1 (0.45) | HTTALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL18571235 | 0.79 | KMT2A (0.44) | HTTALDH1A1KMT2AMEN1MMP1 | |
| SCHEMBL18571269 | 0.79 | ALDH1A1 (0.44) | HTTALDH1A1KMT2AMEN1SLC1A3 | |
| SCHEMBL5121672 | 0.79 | PSIP1 (0.44) | HTTALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL13234055 | 0.79 | KMT2A (0.49) | HTTALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL16000109 | 0.79 | KDM4E (0.50) | HTTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL2993430 | 0.79 | ALDH1A1 (0.44) | HTTALDH1A1KMT2AMEN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137164-B1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2015-08-26 | — | — | EP | disclosed |