Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703554 | 0.80 | ALDH1A1 (0.37) | PPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL818076 | 0.77 | PPM1B (0.38) | CHRM2CHRM4CHRM3CHRNB2CHRNA4 | |
| SCHEMBL3861835 | 0.74 | — | — | |
| SCHEMBL13042109 | 0.69 | PPM1B (0.41) | PPM1BPTPN1PPP1CCALDH1A1TP53 | |
| SCHEMBL6641149 | 0.69 | — | — | |
| SCHEMBL15324962 | 0.69 | — | — | |
| SCHEMBL386334 | 0.69 | — | — | |
| SCHEMBL8122200 | 0.69 | — | — | |
| SCHEMBL28643823 | 0.69 | — | — | |
| SCHEMBL8816181 | 0.69 | CHRM2 (0.35) | CHRM2CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440530-A1 | PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES | Dow AgroSciences LLC (US) | 2012-04-18 | — | — | EP | disclosed |
| EP-2440526-A1 | 3-HALO-6-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES | Dow AgroSciences LLC (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144380-A1 | PROCESS FOR THE PREPARATION OF 6-(ARYL)-4-AMINOPICOLINATES | DOW AGROSCIENCES LLC (US) | 2010-12-16 | — | — | WO | disclosed |
| WO-2010144379-A1 | 3-HALO-(ARLY)-4-IMINOTETRAHYDROPICOLINATES AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2010-12-16 | — | — | WO | disclosed |
| WO-2009076387-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-06-18 | — | — | WO | disclosed |
| EP-1965796-A2 | 4,7-DIHYDROTHIENO[2,3-B]PYRIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS | Gilead Colorado, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| EP-1962840-A1 | USE OF 4, 7-DIHYDROTHIENO [2, 3-B]PYRIDINE COMPOUNDS IN THE TREATMENT OF CARDIOVASCULAR DISEASES | Gilead Colorado, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007076379-A2 | 4,7-DIHYDROTHIENO[2,3-B]PYRIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS | GILEAD COLORADO, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007073555-A1 | USE OF 4, 7-DIHYDROTHIENO [2, 3-B] PYRIDINE COMPOUNDS IN THE TREATMENT OF CARDIOVASCULAR DISEASES | GILEAD COLORADO, INC. (US) | 2007-06-28 | — | — | WO | disclosed |