Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 9/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CSF1R | P07333 | 4/20 | 0.61 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | IDH2 | P48735 | 1/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16670141 | 0.88 | HTT (0.69) | RXFP1MEN1KMT2AP2RX1MAPT | |
| SCHEMBL29561761 | 0.88 | HTT (0.69) | RXFP1MEN1KMT2AP2RX1MAPT | |
| SCHEMBL15529261 | 0.81 | RXFP1 (1.00) | RXFP1MEN1KMT2ATSHRCSF1R | |
| SCHEMBL5178391 | 0.80 | MEN1 (1.00) | RXFP1MEN1KMT2ATSHRCSF1R | |
| SCHEMBL1032356 | 0.80 | CSF1R (0.54) | RXFP1MEN1KMT2ATSHRCSF1R | |
| SCHEMBL6774617 | 0.79 | CHRNB2 (0.71) | MEN1KMT2AMAPT | |
| SCHEMBL4978213 | 0.78 | KDR (0.79) | RXFP1MEN1KMT2ATSHRCSF1R | |
| SCHEMBL1034424 | 0.78 | CSF1R (0.52) | RXFP1MEN1KMT2ATSHRCSF1R | |
| SCHEMBL14372340 | 0.78 | ATR (0.66) | MEN1KMT2AMAPTBRAFABL1 | |
| SCHEMBL7608638 | 0.77 | KMT2A (0.58) | RXFP1MEN1KMT2ATSHRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440058-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USES | Dana-Farber Cancer Institute, Inc. (US) | 2012-04-18 | — | — | EP | disclosed |