Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17033996 | 0.87 | L3MBTL1 (0.65) | SMN1; SMN2L3MBTL1KMT2AGAAHSD17B10 | |
| SCHEMBL9691071 | 0.86 | KAT6A (0.55) | PARP1SMN1; SMN2MRGPRX4L3MBTL1KMT2A | |
| SCHEMBL14233914 | 0.85 | KAT6A (0.58) | PARP1SMN1; SMN2MRGPRX4L3MBTL1KMT2A | |
| SCHEMBL9713054 | 0.84 | SMN1; SMN2 (0.67) | PARP1SMN1; SMN2L3MBTL1KMT2AGAA | |
| SCHEMBL14081049 | 0.83 | LOXL2 (0.61) | PARP1SMN1; SMN2MRGPRX4L3MBTL1KMT2A | |
| SCHEMBL21872371 | 0.83 | L3MBTL1 (0.51) | PARP1SMN1; SMN2MRGPRX4L3MBTL1KMT2A | |
| SCHEMBL27272636 | 0.83 | SMN1; SMN2 (0.54) | PARP1SMN1; SMN2MRGPRX4L3MBTL1KMT2A | |
| SCHEMBL2542308 | 0.83 | PARP1 (0.51) | PARP1SMN1; SMN2MRGPRX4L3MBTL1KMT2A | |
| SCHEMBL13761327 | 0.83 | PARP1 (0.51) | PARP1SMN1; SMN2MRGPRX4L3MBTL1KMT2A | |
| SCHEMBL18265510 | 0.83 | SLC7A5 (0.59) | MRGPRX4KMT2AMEN1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534152-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-02 | — | — | EP | disclosed |
| US-9557336-B2 | Methods and compositions for site-specific labeling of peptides and proteins | UNIVERSITY OF ROCHESTER (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150241440-A1 | METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS | NATIONAL SCIENCE FOUNDATION | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150241440-A1 | METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS | PTMS, ACP1, QPCTL | PARP1 4650/4885SMN1; SMN2 4029/4885MRGPRX4 4024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.