Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.54 |
| ▸ | KIT | P10721 | 7/20 | 0.49 |
| ▸ | FLT3 | P36888 | 7/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 6/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.46 |
| ▸ | CSF1R | P07333 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | LYN | P07948 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.46 |
| ▸ | BLK | P51451 | 3/20 | 0.46 |
| ▸ | BCR | P11274 | 4/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636403 | 0.91 | KDR (0.48) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL27636405 | 0.89 | KDR (0.47) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL27636382 | 0.88 | KDR (0.60) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL4784983 | 0.87 | KDR (0.62) | KDRKITFLT3ABL1FYN | |
| SCHEMBL27657458 | 0.87 | KDR (0.57) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL28760141 | 0.87 | KDR (0.57) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL27657323 | 0.87 | KDR (0.45) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL27657350 | 0.87 | KDR (0.56) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL27636366 | 0.86 | KDR (0.44) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL27636553 | 0.85 | AURKA (0.47) | KDRKITFLT3AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | claimed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-102417487-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB | 2012-04-18 | — | — | CN | disclosed |
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | disclosed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |