⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28678390 | 0.77 | — | — | |
| SCHEMBL9131053 | 0.74 | ERN1 (0.36) | — | |
| SCHEMBL14555815 | 0.73 | — | — | |
| SCHEMBL14484489 | 0.73 | — | — | |
| SCHEMBL29951683 | 0.73 | — | — | |
| SCHEMBL27977383 | 0.68 | EGFR (0.33) | — | |
| SCHEMBL28170829 | 0.68 | HSP90AA1 (0.31) | — | |
| SCHEMBL28056255 | 0.68 | GRM4 (0.37) | — | |
| SCHEMBL1703145 | 0.68 | — | — | |
| SCHEMBL311862 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098018-A1 | BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF | CYTOKINETICS INC (US) | 2026-04-09 | — | — | US | disclosed |
| US-12441691-B2 | Bicyclic 1,4-diazepanones and therapeutic uses thereof | CYTOKINETICS, INC. (US) | 2025-10-14 | — | — | US | disclosed |
| US-20240368091-A1 | BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF | CYTOKINETICS, INC. | 2024-11-07 | — | — | US | disclosed |
| US-11981644-B2 | Bicyclic 1,4-diazepanones and therapeutic uses thereof | CYTOKINETICS, INC. (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4240724-A1 | BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF | Cytokinetics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116635378-A | Bicyclic 1, 4-diazacycloheptanones and therapeutic uses thereof | 赛特凯恩蒂克公司 | 2023-08-22 | — | — | CN | disclosed |
| US-20230083960-A1 | BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF | CYTOKINETICS, INC. | 2023-03-16 | — | — | US | disclosed |
| WO-2022099011-A1 | BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF | CYTOKINETICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| WO-2022099011-A1 | BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF | CYTOKINETICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| EP-2427451-B1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| US-9040531-B2 | Alpha helix mimetics and methods relating thereto | Prism BioLab Co., Ltd. (JP) | 2015-05-26 | — | — | US | disclosed |
| WO-2014071298-A1 | CYCLIC SULFONAMIDE CONTAINING DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAY | NANT HOLDINGS IP, LLC (US) | 2014-05-08 | — | — | WO | disclosed |
| CN-101098855-B | 3- [2- (3-amido-2-oxo-2H-pyridin-1-yl) -acetylamino ] -4-oxo-pentanoic acid derivatives and their use as caspase inhibitors | VERTEX PHARMA | 2012-06-06 | — | — | CN | disclosed |
| US-20120088770-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CORPORATION (JP) | 2012-04-12 | — | — | US | disclosed |
| US-20120088770-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CORPORATION (JP) | 2012-04-12 | — | — | US | disclosed |
| WO-2010128685-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CORPORATION (JP) | 2010-11-11 | — | — | WO | disclosed |
| CN-101775012-A | Aspartic acid specific cysteine proteinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPO | 2010-07-14 | — | — | CN | disclosed |
| CN-1812972-B | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPO | 2010-04-28 | — | — | CN | disclosed |
| CN-101098855-A | 3- [2- (3-amido-2-oxo-2H-pyridin-1-yl) -acetylamino ] -4-oxo-pentanoic acid derivatives and their use as caspase inhibitors | VERTEX PHARMA (US) | 2008-01-02 | — | — | CN | disclosed |
| CN-1812972-A | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPO (US) | 2006-08-02 | — | — | CN | disclosed |