Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332848 | 0.89 | RIPK1 (0.60) | RIPK1EPHX2ROCK2ROCK1MAPK13 | |
| SCHEMBL23316729 | 0.85 | RIPK1 (0.57) | RIPK1EPHX2ROCK2ROCK1MAPK13 | |
| SCHEMBL31034468 | 0.85 | RIPK1 (0.57) | RIPK1EPHX2ROCK2ROCK1MAPK13 | |
| SCHEMBL891888 | 0.85 | RIPK1 (0.57) | RIPK1EPHX2ROCK2ROCK1MAPK13 | |
| SCHEMBL29145674 | 0.84 | LMNA (0.56) | EPHX2TACR3 | |
| SCHEMBL3311541 | 0.81 | RIPK1 (0.60) | RIPK1EPHX2ROCK2ROCK1MAPK13 | |
| SCHEMBL668277 | 0.81 | RIPK1 (0.60) | RIPK1EPHX2ROCK2ROCK1MAPK13 | |
| SCHEMBL117597 | 0.81 | RIPK1 (0.60) | RIPK1EPHX2ROCK2ROCK1MAPK13 | |
| SCHEMBL4337456 | 0.79 | RIPK1 (0.58) | RIPK1EPHX2ROCK2ROCK1MAPK13 | |
| SCHEMBL25159633 | 0.79 | RIPK1 (0.54) | RIPK1EPHX2ROCK2ROCK1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102803252-A | Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases | UNIV LEUVEN KATH | 2012-11-28 | — | — | CN | disclosed |
| EP-2440550-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-04-18 | — | — | EP | disclosed |