Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | CTSK | P43235 | 4/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.53 |
| ▸ | LTA4H | P09960 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17040115 | 0.89 | HDAC8 (0.55) | HDAC8CTSKCTSSLTA4HNPC1 | |
| SCHEMBL17040117 | 0.85 | HDAC8 (0.52) | HDAC8CTSKCTSSLTA4HNPC1 | |
| SCHEMBL15062444 | 0.85 | MEN1 (0.65) | CTSKMEN1KMT2ALMNA | |
| SCHEMBL17040010 | 0.84 | MEN1 (0.45) | HDAC8CTSKMEN1KMT2ALMNA | |
| SCHEMBL17040116 | 0.83 | MEN1 (0.56) | HDAC8CTSKMEN1KMT2ALMNA | |
| SCHEMBL17040014 | 0.81 | SIRT2 (0.46) | HDAC8CTSKSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17040009 | 0.81 | SIRT2 (0.45) | HDAC8CTSKMEN1KMT2ALMNA | |
| SCHEMBL17040118 | 0.80 | SIRT2 (0.55) | HDAC8CTSKCTSSMEN1KMT2A | |
| SCHEMBL17040013 | 0.79 | SIRT2 (0.55) | HDAC8CTSKCTSSMEN1KMT2A | |
| SCHEMBL17556931 | 0.75 | HDAC8 (0.67) | HDAC8CTSKCTSSALDH1A1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015123783-A1 | CATHEPSIN B-TARGETING PROBES | THUNDER BAY REGIONAL RESEARCH INSTITUTE (CA) | 2015-08-27 | — | — | WO | disclosed |