Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | CPA1 | P15085 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | GLI1 | P08151 | 1/20 | 0.46 |
| ▸ | GLI2 | P10070 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17037439 | 0.91 | MTNR1A (0.48) | CYP2D6CYP2C9CYP2C19KMT2AMTNR1A | |
| SCHEMBL14521486 | 0.84 | MTNR1A (0.72) | KMT2AMTNR1AMTNR1BNQO2KDM4E | |
| SCHEMBL8493643 | 0.83 | RECQL (0.55) | MTNR1AMTNR1BHRH1 | |
| SCHEMBL14521444 | 0.81 | CYP2D6 (0.61) | CYP2D6CYP2C9CYP2C19KMT2APOLB | |
| SCHEMBL17040294 | 0.78 | GLI1 (0.64) | CYP2D6CYP2C9CYP2C19KMT2AGLI1 | |
| SCHEMBL24018828 | 0.77 | HRH1 (0.61) | CYP2D6CYP2C9HRH1L3MBTL1RIPK1 | |
| SCHEMBL10310258 | 0.77 | HRH1 (0.57) | MTNR1AMTNR1BHRH1L3MBTL1RIPK1 | |
| SCHEMBL31539989 | 0.77 | HRH1 (0.53) | MTNR1AMTNR1BHRH1KDM4EL3MBTL1 | |
| SCHEMBL18997892 | 0.75 | KMT2A (0.57) | CYP2D6CYP2C9CYP2C19KMT2AMTNR1A | |
| SCHEMBL7866857 | 0.75 | KMT2A (0.81) | CYP2D6CYP2C9CYP2C19KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK CANADA INC. (CA) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | SYK, BTK, TYRO3 | CYP2D6 2313/4885CYP2C9 964/4885CYP2C19 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.