Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.77 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.58 |
| ▸ | CNR2 | P34972 | 4/20 | 0.54 |
| ▸ | CNR1 | P21554 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12319404 | 0.87 | ALOX5 (1.00) | ALOX5GABRA1GABRB2CNR2CNR1 | |
| SCHEMBL28653265 | 0.87 | CNR1 (0.61) | ALOX5GABRA1GABRB2CNR2CNR1 | |
| SCHEMBL1024663 | 0.85 | HPGD (0.57) | ALOX5CNR2CNR1BACE1NPC1 | |
| SCHEMBL9818748 | 0.84 | ALOX5 (0.58) | ALOX5GABRA1GABRB2CNR2CNR1 | |
| SCHEMBL28055345 | 0.83 | HPGD (0.55) | ALOX5CNR2CNR1BACE1NPC1 | |
| Phosphine SCHEMBL28136514 | 0.83 | HPGD (0.55) | ALOX5CNR2CNR1BACE1NPC1 | |
| SCHEMBL723543 | 0.83 | CNR1 (0.77) | ALOX5CNR2CNR1POLBNPC1 | |
| SCHEMBL30708512 | 0.83 | TYR (0.55) | ALOX5GABRA1GABRB2MEN1MAPT | |
| SCHEMBL17709428 | 0.83 | TYR (0.55) | ALOX5GABRA1GABRB2MEN1MAPT | |
| SCHEMBL29138357 | 0.83 | BACE1 (0.69) | ALOX5GABRA1GABRB2CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | COLGATE-PALMOLIVE COMPANY | 2017-04-27 | — | — | US | disclosed |
| US-8425881-B2 | Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods | COLGATE-PALMOLIVE COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| EP-1863432-B1 | Antiplaque 3',5-disubstituted 2,4'-dihydroxybiphenyl compounds and toothpaste composition | COLGATE PALMOLIVE CO (US) | 2012-04-18 | — | — | EP | disclosed |
| EP-1863432-A1 | ANTIBACTERIAL 3',5-DISUBSTITUTED 2,4'-DIHYDROXYBIPHENYL COMPOUNDS, DERIVATIVES AND RELATED METHODS | Colgate-Palmolive Company (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006101818-A1 | ANTIBACTERIAL 3',5-DISUBSTITUTED 2,4'-DIHYDROXYBIPHENYL COMPOUNDS, DERIVATIVES AND RELATED METHODS | COLGATE-PALMOLIVE COMPANY (US) | 2006-09-28 | — | — | WO | disclosed |
| US-20060210489-A1 | Antibacterial 3',5-disubstituted 2,4'-dihydroxybiphenyl compounds, derivatives and related methods | COLGATE-PALMOLIVE | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170113989-A1 | SYNTHESIS OF HONOKIOL | UGT2B7, UGT1A7, DHCR7 | ALOX5 374/4885GABRA1 395/4885GABRB2 320/4885 |
| US-20060210489-A1 | Antibacterial 3',5-disubstituted 2,4'-dihydroxybiphenyl compounds, derivatives and related methods | DRD4, QDPR, TPD52L2 | ALOX5 2265/4885GABRA1 4052/4885GABRB2 4101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.