Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 17/20 | 0.62 |
| ▸ | NMT1 | P30419 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704904 | 0.86 | KARS1 (0.68) | KARS1NMT1DYRK1AATR | |
| SCHEMBL1704095 | 0.78 | KARS1 (0.62) | KARS1 | |
| SCHEMBL1704222 | 0.77 | KARS1 (1.00) | KARS1 | |
| SCHEMBL901708 | 0.75 | KARS1 (0.66) | KARS1DYRK1A | |
| SCHEMBL902600 | 0.74 | KARS1 (1.00) | KARS1 | |
| SCHEMBL1704254 | 0.74 | KARS1 (0.59) | KARS1NMT1ATR | |
| SCHEMBL1755643 | 0.73 | KARS1 (1.00) | KARS1 | |
| SCHEMBL901826 | 0.73 | KARS1 (0.60) | KARS1 | |
| SCHEMBL902386 | 0.72 | KARS1 (0.75) | KARS1 | |
| SCHEMBL1755689 | 0.72 | KARS1 (0.75) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |