Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 17/20 | 0.66 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902032 | 0.88 | KARS1 (0.52) | KARS1PRKD1 | |
| SCHEMBL901245 | 0.87 | KARS1 (0.52) | KARS1PRKD1 | |
| SCHEMBL901861 | 0.86 | KARS1 (0.66) | KARS1PRKD1PRKD2DYRK1A | |
| SCHEMBL1704872 | 0.86 | KARS1 (0.48) | KARS1PRKD1PRKD2DYRK1A | |
| SCHEMBL901736 | 0.85 | KARS1 (0.51) | KARS1PRKD1 | |
| SCHEMBL901702 | 0.85 | KARS1 (0.51) | KARS1DYRK1A | |
| SCHEMBL1755605 | 0.85 | KARS1 (0.52) | KARS1PRKD1PRKD2DYRK1A | |
| SCHEMBL902796 | 0.85 | KARS1 (0.47) | KARS1PRKD1DYRK1A | |
| SCHEMBL901688 | 0.85 | KARS1 (0.48) | KARS1 | |
| SCHEMBL901846 | 0.84 | KARS1 (0.46) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |