Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | SELP | P16109 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815479 | 1.00 | P2RX3 (0.58) | P2RX3SMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL17043078 | 0.90 | P2RX3 (0.62) | P2RX3L3MBTL1KDM4EHSD17B10ADAMTS4 | |
| SCHEMBL17043074 | 0.90 | P2RX3 (0.62) | P2RX3L3MBTL1KDM4EHSD17B10ADAMTS4 | |
| SCHEMBL1306254 | 0.87 | P2RX3 (0.60) | P2RX3L3MBTL1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL1306250 | 0.87 | P2RX3 (0.60) | P2RX3L3MBTL1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL1306515 | 0.86 | P2RX3 (0.63) | P2RX3SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL1306516 | 0.86 | P2RX3 (0.63) | P2RX3SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL1305919 | 0.85 | SMN1; SMN2 (0.46) | P2RX3SMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1305922 | 0.85 | SMN1; SMN2 (0.46) | P2RX3SMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1306401 | 0.85 | P2RX3 (0.58) | P2RX3L3MBTL1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2913322-A2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | Korea Research Institute Of Chemical Technology (KR) | 2015-09-02 | — | — | EP | disclosed |