Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | BMP1 | P13497 | 1/20 | 0.45 |
| ▸ | SLC26A6 | Q9BXS9 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL892934 | 0.92 | MMP2 (0.51) | MMP2BMP1SLC26A6PRSS1PRSS2 | |
| SCHEMBL892951 | 0.82 | KMT2A (0.54) | SLC26A6SMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL892714 | 0.81 | SLC26A6 (0.48) | MMP2BMP1SLC26A6PRSS1PRSS2 | |
| SCHEMBL892994 | 0.80 | MAPT (0.51) | SLC26A6PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL892478 | 0.80 | SLC26A6 (0.53) | MMP2BMP1SLC26A6SMN1; SMN2RAB9A | |
| SCHEMBL892925 | 0.79 | SLC26A6 (0.52) | SLC26A6PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL31485363 | 0.79 | PRSS1 (0.49) | PRSS1PRSS2PRSS3TPSAB1SMN1; SMN2 | |
| SCHEMBL892484 | 0.78 | SLC26A6 (0.55) | MMP2BMP1SLC26A6SMN1; SMN2POLB | |
| SCHEMBL892555 | 0.77 | SMN1; SMN2 (0.43) | MMP2BMP1SLC26A6PRSS1PRSS2 | |
| SCHEMBL892476 | 0.77 | SLC26A6 (0.53) | SLC26A6POLBKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440550-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142801-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-12-16 | — | — | WO | disclosed |