Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | COMT | P21964 | 4/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17044085 | 0.91 | KDR (0.46) | KDM4ERIPK2RETKDRMAPK14 | |
| SCHEMBL17044064 | 0.87 | RIPK2 (0.49) | KDM4ERIPK2RETKDRMAPK14 | |
| SCHEMBL17044086 | 0.86 | RIPK2 (0.43) | KDM4ERIPK2RETKDRMAPK14 | |
| SCHEMBL17044114 | 0.85 | RET (0.60) | RIPK2RETKDRMAPK14PKMYT1 | |
| SCHEMBL17044063 | 0.84 | KDR (0.46) | KDM4ERIPK2RETKDRMAPK14 | |
| SCHEMBL17044107 | 0.84 | MMP2 (0.43) | KDM4ERIPK2PTGDR2COMTMMP2 | |
| SCHEMBL17044112 | 0.82 | GAA (0.45) | RIPK2RETKDRMAPK14PKMYT1 | |
| SCHEMBL17044075 | 0.82 | MMP2 (0.43) | KDM4ERIPK2MAPK14PTGDR2COMT | |
| SCHEMBL17044098 | 0.81 | RET (0.42) | KDM4ERETPTGDR2NR1H2NR1H3 | |
| SCHEMBL17044067 | 0.81 | KDM4E (0.44) | KDM4ERIPK2PTGDR2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | claimed |